When traditional antidepressants aren’t enough.
Treatment-Resistant Depression (TRD) is major depression that has not responded to at least two different antidepressants. It is a common medical condition that simply requires a more specialized approach.
We specialize in advanced, proven solutions for TRD, offering new hope through innovative therapies like SPRAVATO® (esketamine), designed for those who haven’t found relief.
TRD symptoms mirror major depression but are defined by their persistence, even after trying at least two different antidepressants. If this sounds familiar, you may have TRD, and specialized treatment could be the answer.

A constant feeling of sadness, hopelessness, or emptiness that doesn't lift, despite treatment.

A deep, lasting exhaustion and lack of energy that isn't solved by sleep and interferes with daily life.

A reduced ability to feel pleasure or find joy in activities, hobbies, and relationships.

Persistent "brain fog," including trouble concentrating, remembering, or making decisions.
Talk therapy, such as CBT, is a foundational tool to build coping strategies and change negative thought patterns, and is often used in combination with other treatments.
We will conduct a thorough review of your medication history and may adjust, switch, or augment your current antidepressants to find a more effective combination.
SPRAVATO® is an FDA-approved nasal spray designed for TRD that works differently than oral antidepressants by targeting the brain’s glutamate system.
Reclaim your life from treatment-resistant depression and other mental health challenges. EverHope offers expert care and personalized depression treatments in Delaware, OH to help you feel like your best self.
